Endocrine Abstracts

Phytotherapy is the integral part of the combined treatment for diabetes mellitus. A large number of plants possessing hypoglycemic activity are described in the literature, but only small part of them is in use. Hypoglycemic effect of medicinal plants is preconditioned by the wide spectrum of compounds with biological activity in their composition. Flowers of carthamus (Carthamus tinctorius) and leaves of celery (Apium graveolens) are known to possess a numb...

Sphingolipids constitute the structural base for all types of biological membranes, and are numerous in human and animal tissues. Metabolites of sphingolipids act as biological effectors, modulators and mediators in a number of biochemical processes; they are known to be pathogens in various human pathologies.We aimed at studying activity of sphingomyelinase, concentrations of sphingomyelin and its metabolites, such as ceramide and sphingosine, in organs...

According to the findings from the recent studies, the oxidative stress can be a cause for type 2 diabetes mellitus onset. In that context, the development of drugs with antioxidant effect to be used for prevention and treatment of the disease is of vital importance. The work was initiated to study the oxidative stress in the experimental diabetes and methods of its correction by means of natural antioxidants. In our study we used polyphenols isolated from the seeds of common ...

Disturbance in insulin signaling under effect of sphingolipids is thought to be the mechanism underlying the obesity-mediated insulin resistance. The work was initiated to study sphingolipid metabolism in tissues of rats with obesity induced by a prolonged high-calorie diet. The lipid extraction and purification was performed by Folch’s method; concentrations of sphingosine and ceramide were measured by Lauter et al. method. In obesity, the levels of total gangli...

The work was initiated to study some biochemical parameters in peripheral blood of animals upon diet-induced obesity and insulin resistance modeling. Obesity was induced in BALB/c mice by keeping them on the high- carbon diet for 13 weeks. The commercially available kits were used to assay glucose, alkaline phosphatase, creatine kinase and cholesterol; concentrations of testosterone were measured by the enzyme immunoassay. The high carbon diet in BALB/c mice served as a basis ...